Canberra scored five times in the top of the first inning, and Tim Atherton picked up his third win.
After dropping five of seven games by one or two runs, Melbourne turned the tables in Friday's win.
Stefan Welch and Angus Roeger drove in five of their team's six runs with Friday homers against the Bandits.
The Bite scored 13 consecutive runs to seize their Round 4 opener with a dominant victory over the Bandits.
Sydney needed just two hits to plate five runs and claim a series-opening victory on the road at Melbourne.