Two teams in playoff position entering Round 8 collide when Canberra head north to Brisbane for a four-game set.
The Aces have slipped to four games back of a playoff spot and need a strong finish to their series against the Heat.
Adelaide have won four of their five meetings with Sydney this season. The Sox hope for different luck on Friday.
Perth trailed twice but erupted for five runs in the fifth and six in the ninth to rout Melbourne on Thursday night.
Adelaide scored six runs in the bottom of the first and cruised the rest of the way in a series-opening win over Sydney.