Tied at 4-4 entering the 13th, Canberra broke out for seven runs in extras to seize a series-opening victory.
A night after giving up 15 runs, Melbourne crushed Perth behind Kellin Deglan's big effort at the plate.
After trailing early, the Bite grabbed the lead in the third inning and didn't look back on the way to a Friday night win.
Perth trailed twice but erupted for five runs in the fifth and six in the ninth to rout Melbourne on Thursday night.
Adelaide scored six runs in the bottom of the first and cruised the rest of the way in a series-opening win over Sydney.